In this project, we were developing and implementing a PAT methodology to control the manufacturing process of heparin production using NMR. The project involved different aspects, including a fundamental study on the regions of the NMR spectrum that are active in the anti-coagulation process. Next, we tried to develop a method to calculate the heparin potency using NMR analysis. The objective was to construct a surrogate model aimed to control the heparin production during the manufacturing process in order to increase the product quality and decrease costs.
There is a non-disclosure agreement (NDA) for this project and I am not authorised to discuss any details.
Covered by NDA agreement.